Seminar by Yuji Sakai – University of Copenhagen

Seminar by Yuji Sakai

Modeling of autophagosome formation

Yuji Sakai 

Assistant Professor, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo

Abstract:
We discuss the mechanism of autophagosome formation from a physical point of view. 
In the dynamics, a shape transition occurs from flat to curled membrane while some proteins localize at the rim. 
We make a model that incorporates both dynamics of the shape transition and the protein partitioning. 
Our model recapitulates and explains features of the dynamics of the autophagosome formation.