Seminar by Yuji Sakai – University of Copenhagen

Seminar by Yuji Sakai

Modeling of autophagosome formation

Yuji Sakai 

Assistant Professor, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo

We discuss the mechanism of autophagosome formation from a physical point of view. 
In the dynamics, a shape transition occurs from flat to curled membrane while some proteins localize at the rim. 
We make a model that incorporates both dynamics of the shape transition and the protein partitioning. 
Our model recapitulates and explains features of the dynamics of the autophagosome formation.