Seminar by Emma Hammarlund – University of Copenhagen

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Center for Models of Life > Meetings & Seminars > 2018 > Seminar by Emma Hammar...

Seminar by Emma Hammarlund

When Earth’s surface changed through a modified cellular mechanism, such that animals could enter its oxic niches: A hypothesis based on clues from tumors and rocks.

Emma Hammarlund, Translational Cancer Reserach, Lund University

Why and how animals diversified dramatically in the Cambrian remains an enigma. Since long, we have presumed the event relates to an increase in oxic niches, and the ongoing hunt for geological evidence hereof is at record high intensity. Meanwhile, other scientific disciplines have noted that multicellularity remains viable through a smaller pool of immature cells (i.e. with high stemness) that – quite absolutely – requires low oxygen conditions. Therefore, a yet unnoticed paradox emerge: How can animals like us renew tissue through hypoxia-driven cell stemness despite a life in the oxic realm? I will present clues from the field of tumor biology that can be applied to the geobiological enigma of animal diversification on Earth, where also observations of primordial multicellularity and oxic conditions fit.